| W | Player | Team | Season |
| 27 | Denny McLain | John | 3 |
| 25 | Denny McLain | Dan | 4 |
| Bob Gibson | Dan | 3 |
| ERA | Player | Team | Season |
| 2.31 | Nelson Briles | John | 17 |
| 2.37 | Sandy Koufax | John | 14 |
| 2.47 | Luis Tiant | John | 9 |
| 2.51 | Nolan Ryan | Eugene | 4 |
| K | Player | Team | Season |
| 433 | Tom Hall | John | 4 |
| 425 | Dwight Gooden | Eugene | 3 |
| 399 | Dwight Gooden | Dan | 4 |
| IP | Player | Team | Season |
| 359.1 | Sam McDowell | Eugene | 3 |
| 352.2 | Luis Tiant | Eug/John | 6 |
| 352.1 | Dwight Gooden | Dan | 1 |
| Dwight Gooden | Eugene | 3 |
| CG | Player | Team | Season |
| 32 | Bob Gibson | Eugene | 4 |
| Luis Tiant | Louis | 4 |
| Tom Seaver | Eugene | 6 |
| ShO | Player | Team | Season |
| 9 | Sandy Koufax | John | 14 |
| Juan Marichal | Joe | 14 |
| 8 | Nolan Ryan | Eugene | 4 |
| Eric Rasmussen | John | 9 |
| BB | Player | Team | Season |
| 206 | Nolan Ryan | Eugene | 5 |
| 194 | Nolan Ryan | Eugene | 6 |
| 183 | Dwight Gooden | Dan/John | 5 |
| L | Player | Team | Season |
| 30 | Ron Guidry | Eugene | 3 |
| 28 | JR Richard | Eugene | 3 |
| 24 | Sam McDowell | Dan/John | 6 |
|
| W | Player | Team | Season |
| 34 | Ray Narleski | Joe | 8 |
| 33 | Dennis Eckersley | Dan | 7 |
| 32 | Hoyt Wilhelm | Joe | 14 |
| S | Player | Team | Season |
| 52 | Trevor Hoffman | Mike | 12 |
| 43 | Dennis Eckersley | John | 6 |
| 42 | Goose Gossage | Mike/John | 7 |
| ERA | Player | Team | Season |
| 1.51 | Jim Brewer | Joe | 17 |
| 1.57 | Ken Sanders | Dan | 6 |
| 1.62 | Dave Guisti | John | 16 |
| 1.68 | Trevor Hoffman | Mike | 12 |
| K | Player | Team | Season |
| 553 | Bruce Sutter | Lou | 3 |
| 544 | Bruce Sutter | Dan | 9 |
| 412 | Dennis Eckersley | Dan | 7 |
| G | Player | Team | Season |
| 146 | Don McMahon | Joe | 13 |
| 139 | Hoyt Wilhelm | Joe | 14 |
| 130 | Bruce Sutter | Lou | 3 |
| Dennis Eckersley | Dan | 7 |
| IP | Player | Team | Season |
| 491.0 | Bruce Sutter | Lou | 3 |
| 481.1 | Dennis Eckersley | Dan | 7 |
| 439.1 | Bruce Sutter | Dan | 9 |
| L | Player | Team | Season |
| 28 | Bud Thomas | Glenn | 10 |
| 21 | Bruce Sutter | Dan | 9 |
| 20 | Bruce Sutter | John | 8 |
|